Pseudomonas aeruginosa PAO1, PA1673 (mhr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1673
Name
mhr
Replicon chromosome
Genomic location 1824969 - 1825430 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250364.1
GI 15596870
Affymetrix PA1673_at
DNASU PaCD00006758
Entrez 879280
GenBank AAG05062.1
INSDC AAG05062.1
NCBI Locus Tag PA1673
protein_id(GenBank) gb|AAG05062.1|AE004595_1|gnl|PseudoCAP|PA1673
TIGR NTL03PA01674
UniParc UPI000012C5BD
UniProtKB Acc Q9I352
UniProtKB ID HEMTB_PSEAE
UniRef100 UniRef100_B7UV48
UniRef50 UniRef50_B7UV48
UniRef90 UniRef90_B7UV48

Product

Feature Type CDS
Coding Frame 1
Product Name
microoxic hemerythrin, Mhr
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.60
Kyte-Doolittle Hydrophobicity Value -0.517
Molecular Weight (kDa) 17.9
Isoelectric Point (pI) 6.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 139 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003717 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1673
Search term: mhr

Human Homologs

References

Structural studies on Dendrostomum pyroides hemerythrin.
Ferrell RE, Kitto GB
Biochemistry 1971 Jul 20;10(15):2923-9
PubMed ID: 5114534
The dcr gene family of Desulfovibrio: implications from the sequence of dcrH and phylogenetic comparison with other mcp genes.
Deckers HM, Voordouw G
Antonie Van Leeuwenhoek 1996 Jul;70(1):21-9
PubMed ID: 8836438
Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin.
Clay ME, Hammond JH, Zhong F, Chen X, Kowalski CH, Lee AJ, Porter MS, Hampton TH, Greene CS, Pletneva EV, Hogan DA
Proc Natl Acad Sci U S A 2020 Feb 11;117(6):3167-3173
PubMed ID: 31980538