Pseudomonas aeruginosa PAO1, PA1707 (pcrH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1707
Name
pcrH
Replicon chromosome
Genomic location 1853181 - 1853684 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250398.1
GI 15596904
Affymetrix PA1707_pcrH_at
Entrez 879267
GenBank AAG05096.1
INSDC AAG05096.1
NCBI Locus Tag PA1707
protein_id(GenBank) gb|AAG05096.1|AE004597_10|gnl|PseudoCAP|PA1707
TIGR NTL03PA01708
UniParc UPI00000C5455
UniProtKB Acc Q9I325
UniProtKB ID Q9I325_PSEAE
UniRef100 UniRef100_Q9I325
UniRef50 UniRef50_P21207
UniRef90 UniRef90_Q9I325

Product

Feature Type CDS
Coding Frame 1
Product Name
regulatory protein PcrH
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -10.14
Kyte-Doolittle Hydrophobicity Value -0.351
Molecular Weight (kDa) 18.4
Isoelectric Point (pI) 4.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4JL0 CHAPERONE 03/12/13 Crystal structure of PcrH in complex with the chaperone binding region of PopB Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT 2.22 X-RAY DIFFRACTION 100.0
2XCB PROTEIN BINDING 04/22/10 Crystal structure of PcrH in complex with the chaperone binding region of PopD PSEUDOMONAS AERUGINOSA; SYNTHETIC CONSTRUCT 1.85 X-RAY DIFFRACTION 100.0
2XCC PROTEIN BINDING 04/22/10 Crystal structure of PcrH from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.13 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB : VF0083
Category T3SS
Evidence
Host Organism
Notes
Reference 11372029

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 35 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003682 (311 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1707
Search term: pcrH

Human Homologs

References

Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon.
Yahr TL, Mende-Mueller LM, Friese MB, Frank DW
J Bacteriol 1997 Nov;179(22):7165-8
PubMed ID: 9371466