Pseudomonas aeruginosa PAO1, PA1750

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1750
Name
Replicon chromosome
Genomic location 1890739 - 1891815 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250441.1
GI 15596947
Affymetrix PA1750_at
Entrez 882053
GenBank AAG05139.1
INSDC AAG05139.1
NCBI Locus Tag PA1750
protein_id(GenBank) gb|AAG05139.1|AE004601_4|gnl|PseudoCAP|PA1750
TIGR NTL03PA01751
UniParc UPI00000C547B
UniProtKB Acc Q9I2Y7
UniProtKB ID Q9I2Y7_PSEAE
UniRef100 UniRef100_Q9I2Y7
UniRef50 UniRef50_A5F8Y4
UniRef90 UniRef90_A0A024HF64

Product

Feature Type CDS
Coding Frame 1
Product Name
phospho-2-dehydro-3-deoxyheptonate aldolase
Product Name Confidence: Class 2
Synonyms 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.71
Kyte-Doolittle Hydrophobicity Value -0.256
Molecular Weight (kDa) 39.1
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 260 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003643 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1750

Human Homologs

References

Overexpression, purification, and characterization of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase from Escherichia coli.
Ramilo CA, Evans JN
Protein Expr Purif 1997 Mar;9(2):253-61
PubMed ID: 9056491