Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1818
|
Name |
cadA
Synonym: ldcA Synonym: adi Synonym: ldcC Synonym: speC |
Replicon | chromosome |
Genomic location | 1974821 - 1977076 (+ strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Comment | Modeling evidence, since PAO1 grows on lysine. Also physiological evidence from Fothergill et al. BLAST of Lysine decarboxylase Burkholderia cenocepacia HI2424 vs. P. aeruginosa PAO1 genome gave E = 0 with PA1818. Orn and Arg functions are also in reconstruction. |
RefSeq | NP_250509.1 |
GI | 15597015 |
Affymetrix | PA1818_at |
Entrez | 878596 |
GenBank | AAG05207.1 |
INSDC | AAG05207.1 |
NCBI Locus Tag | PA1818 |
protein_id(GenBank) | gb|AAG05207.1|AE004608_6|gnl|PseudoCAP|PA1818 |
TIGR | NTL03PA01819 |
UniParc | UPI00000C54AF |
UniProtKB Acc | Q9I2S7 |
UniProtKB ID | Q9I2S7_PSEAE |
UniRef100 | UniRef100_Q9I2S7 |
UniRef50 | UniRef50_I7KDU0 |
UniRef90 | UniRef90_Q9I2S7 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
lysine decarboxylase
|
Synonyms |
Orn/Arg/Lys decarboxylase LdcC lysine-specific pyridoxal 5'-phosphate-dependent carboxylase, LdcA lysine-specific pyridoxal 5’-phosphate-dependent carboxylase, LdcA |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -13.13 |
Kyte-Doolittle Hydrophobicity Value | -0.083 |
Molecular Weight (kDa) | 82.8 |
Isoelectric Point (pI) | 6.07 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6Q6I | OXIDOREDUCTASE | 12/11/18 | Lysine decarboxylase A from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 3.7 | ELECTRON MICROSCOPY | 99.9 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 242 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003580 (469 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1818
Search term: cadA
Search term: lysine decarboxylase
|
Catabolism of L-lysine by Pseudomonas aeruginosa.
Fothergill JC, Guest JR
J Gen Microbiol 1977 Mar;99(1):139-55
PubMed ID: 405455
|
CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.
Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Köhler T
J Biol Chem 2004 Mar 5;279(10):8761-8
PubMed ID: 14679195
|
Genes and enzymes of lysine catabolism in Pseudomonas aeruginosa.
Rahman M, Clarke PH
J Gen Microbiol 1980 Feb;116(2):357-69
PubMed ID: 6768834
|
L-lysine catabolism is controlled by L-arginine and ArgR in Pseudomonas aeruginosa PAO1.
Chou HT, Hegazy M, Lu CD
J Bacteriol 2010 Nov;192(22):5874-80
PubMed ID: 20833801
|
Multiple and interconnected pathways for L-lysine catabolism in Pseudomonas putida KT2440.
Revelles O, Espinosa-Urgel M, Fuhrer T, Sauer U, Ramos JL
J Bacteriol 2005 Nov;187(21):7500-10
PubMed ID: 16237033
|