Pseudomonas aeruginosa PAO1, PA1838 (cysI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1838
Name
cysI
Replicon chromosome
Genomic location 1995148 - 1996806 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_250529.1
GI 15597035
Affymetrix PA1838_cysI_at
Entrez 878581
GenBank AAG05227.1
INSDC AAG05227.1
NCBI Locus Tag PA1838
protein_id(GenBank) gb|AAG05227.1|AE004609_14|gnl|PseudoCAP|PA1838
TIGR NTL03PA01839
UniParc UPI00000C54C2
UniProtKB Acc Q9I2Q7
UniProtKB ID Q9I2Q7_PSEAE
UniRef100 UniRef100_Q9I2Q7
UniRef50 UniRef50_Q9I2Q7
UniRef90 UniRef90_Q9I2Q7

Product

Feature Type CDS
Coding Frame 1
Product Name
sulfite reductase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -9.58
Kyte-Doolittle Hydrophobicity Value -0.297
Molecular Weight (kDa) 62.1
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 432 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001569 (896 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1838
Search term: cysI
Search term: sulfite reductase

Human Homologs

References

Regulation of the sulfate starvation response in Pseudomonas aeruginosa: role of cysteine biosynthetic intermediates.
Hummerjohann J, Küttel E, Quadroni M, Ragaller J, Leisinger T, Kertes MA
Microbiology (Reading) 1998 May;144 ( Pt 5):1375-1386
PubMed ID: 9611812
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994