Pseudomonas aeruginosa PAO1, PA1876

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1876
Name
Replicon chromosome
Genomic location 2045114 - 2047285 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
Commentinvolved in biofilm-specific resistance to a subset of antibiotics

Cross-References

RefSeq NP_250567.1
GI 15597073
Affymetrix PA1876_at
Entrez 882231
GenBank AAG05265.1
INSDC AAG05265.1
NCBI Locus Tag PA1876
protein_id(GenBank) gb|AAG05265.1|AE004613_10|gnl|PseudoCAP|PA1876
TIGR NTL03PA01877
UniParc UPI00000C54E5
UniProtKB Acc Q9I2M1
UniProtKB ID Q9I2M1_PSEAE
UniRef100 UniRef100_S0IGW4
UniRef50 UniRef50_F6AB59
UniRef90 UniRef90_B7VAZ7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable ATP-binding/permease fusion ABC transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 1.42
Kyte-Doolittle Hydrophobicity Value 0.168
Molecular Weight (kDa) 78.2
Isoelectric Point (pI) 7.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001556 (830 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1876

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 3.0e-29
Percent Identity: 25.7

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295