Pseudomonas aeruginosa PAO1, PA1898 (qscR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1898
Name
qscR
Synonym: phzR
Replicon chromosome
Genomic location 2069490 - 2070203 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250589.1
GI 15597095
Affymetrix PA1898_at
DNASU PaCD00006854
Entrez 880650
GenBank AAG05287.1
INSDC AAG05287.1
NCBI Locus Tag PA1898
protein_id(GenBank) gb|AAG05287.1|AE004616_1|gnl|PseudoCAP|PA1898
TIGR NTL03PA01899
UniParc UPI00000D4284
UniProtKB Acc G3XD77
UniProtKB ID G3XD77_PSEAE
UniRef100 UniRef100_W0YR84
UniRef50 UniRef50_W0YR84
UniRef90 UniRef90_W0YR84

Product

Feature Type CDS
Coding Frame 1
Product Name
quorum-sensing control repressor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.35
Kyte-Doolittle Hydrophobicity Value -0.141
Molecular Weight (kDa) 27.3
Isoelectric Point (pI) 5.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6CBQ transcription/agonist 02/05/18 Crystal structure of QscR bound to agonist S3 Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 100.0
6CC0 TRANSCRIPTION 02/05/18 Crystal structure of QscR bound to C12-homoserine lactone Pseudomonas aeruginosa 2.5 X-RAY DIFFRACTION 100.0
3SZT TRANSCRIPTION 07/19/11 Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone Pseudomonas aeruginosa 2.55 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 174 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001096 (1439 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1898
Search term: qscR

Human Homologs

References

QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa.
Chugani SA, Whiteley M, Lee KM, D'Argenio D, Manoil C, Greenberg EP
Proc Natl Acad Sci U S A 2001 Feb 27;98(5):2752-7
PubMed ID: 11226312
Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor.
Lee JH, Lequette Y, Greenberg EP
Mol Microbiol 2006 Jan;59(2):602-9
PubMed ID: 16390453
Phenazine antibiotic biosynthesis in Pseudomonas aureofaciens 30-84 is regulated by PhzR in response to cell density.
Pierson LS 3rd, Keppenne VD, Wood DW
J Bacteriol 1994 Jul;176(13):3966-74
PubMed ID: 8021179
Two-component transcriptional regulation of N-acyl-homoserine lactone production in Pseudomonas aureofaciens.
Chancey ST, Wood DW, Pierson LS 3rd
Appl Environ Microbiol 1999 Jun;65(6):2294-9
PubMed ID: 10347004