Pseudomonas aeruginosa PAO1, PA1920 (nrdD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1920
Name
nrdD
Synonym: nrdD
Replicon chromosome
Genomic location 2094329 - 2096356 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250610.1
GI 15597116
Affymetrix PA1920_at
Entrez 882172
GenBank AAG05308.1
INSDC AAG05308.1
NCBI Locus Tag PA1920
protein_id(GenBank) gb|AAG05308.1|AE004618_2|gnl|PseudoCAP|PA1920
TIGR NTL03PA01920
UniParc UPI00000C550A
UniProtKB Acc Q9I2I4
UniProtKB ID Q9I2I4_PSEAE
UniRef100 UniRef100_W0YSM4
UniRef50 UniRef50_Q8XR96
UniRef90 UniRef90_A6V6P0

Product

Feature Type CDS
Coding Frame 1
Product Name
class III (anaerobic) ribonucleoside-triphosphate reductase subunit, NrdD
Product Name Confidence: Class 2
Synonyms class III (anaerobic) ribonucleoside-triphosphate reductase subunit, NrdD
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.83
Kyte-Doolittle Hydrophobicity Value -0.410
Molecular Weight (kDa) 76.1
Isoelectric Point (pI) 6.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 349 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003498 (383 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1920
Search term: nrdD

Human Homologs

References

Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes.
Torrents E, Poplawski A, Sjöberg BM
J Biol Chem 2005 Apr 29;280(17):16571-8
PubMed ID: 15722359
In vivo selection for Leishmania donovani miniexon genes that increase virulence in Leishmania major.
Zhang WW, Matlashewski G
Mol. Microbiol. 2004 Nov;54(4):1051-62
PubMed ID: 15522086