Pseudomonas aeruginosa PAO1, PA2416 (treA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2416
Name
treA
Replicon chromosome
Genomic location 2698526 - 2700163 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251106.1
GI 15597612
Affymetrix PA2416_treA_at
Entrez 882861
GenBank AAG05804.1
INSDC AAG05804.1
NCBI Locus Tag PA2416
protein_id(GenBank) gb|AAG05804.1|AE004669_1|gnl|PseudoCAP|PA2416
TIGR NTL03PA02416
UniParc UPI00000C56BF
UniProtKB Acc Q9I165
UniProtKB ID TREA_PSEAE
UniRef100 UniRef100_Q9I165
UniRef50 UniRef50_Q9I165
UniRef90 UniRef90_Q9I165

Product

Feature Type CDS
Coding Frame 1
Product Name
periplasmic trehalase precursor
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -1.67
Kyte-Doolittle Hydrophobicity Value -0.530
Molecular Weight (kDa) 61.2
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 86 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003117 (306 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2416
Search term: treA

Human Homologs

Ensembl 110, assembly GRCh38.p14
trehalase [Source:HGNC Symbol;Acc:HGNC:12266]
E-value: 2.0e-70
Percent Identity: 34.2

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Trehalase of Escherichia coli. Mapping and cloning of its structural gene and identification of the enzyme as a periplasmic protein induced under high osmolarity growth conditions.
Boos W, Ehmann U, Bremer E, Middendorf A, Postma P
J Biol Chem 1987 Sep 25;262(27):13212-8
PubMed ID: 2820965
Osmotic induction of the periplasmic trehalase in Escherichia coli K12: characterization of the treA gene promoter.
Repoila F, Gutierrez C
Mol Microbiol 1991 Mar;5(3):747-55
PubMed ID: 1710760