Pseudomonas aeruginosa PAO1, PA2584 (pgsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2584
Name
pgsA
Replicon chromosome
Genomic location 2923367 - 2923927 (- strand)

Cross-References

RefSeq NP_251274.1
GI 15597780
Affymetrix PA2584_pgsA_at
Entrez 880388
GenBank AAG05972.1
INSDC AAG05972.1
NCBI Locus Tag PA2584
protein_id(GenBank) gb|AAG05972.1|AE004687_1|gnl|PseudoCAP|PA2584
TIGR NTL03PA02584
UniParc UPI00000C5752
UniProtKB Acc Q9I0Q2
UniProtKB ID Q9I0Q2_PSEAE
UniRef100 UniRef100_W0YUU9
UniRef50 UniRef50_A6W0B7
UniRef90 UniRef90_W0YUU9

Product

Feature Type CDS
Coding Frame 1
Product Name
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Product Name Confidence: Class 2
Synonyms phosphatidylglycerophosphate synthase
Evidence for Translation
Charge (pH 7) 1.70
Kyte-Doolittle Hydrophobicity Value 0.936
Molecular Weight (kDa) 20.5
Isoelectric Point (pI) 8.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 512 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002962 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2584
Search term: pgsA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli.
Gopalakrishnan AS, Chen YC, Temkin M, Dowhan W
J Biol Chem 1986 Jan 25;261(3):1329-38
PubMed ID: 3003065
Global regulation of expression of antifungal factors by a Pseudomonas fluorescens biological control strain.
Gaffney TD, Lam ST, Ligon J, Gates K, Frazelle A, Di Maio J, Hill S, Goodwin S, Torkewitz N, Allshouse AM
Mol Plant Microbe Interact 1994 Jul-Aug;7(4):455-63
PubMed ID: 8075420