Pseudomonas aeruginosa PAO1, PA2637 (nuoA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2637
Name
nuoA
Replicon chromosome
Genomic location 2982781 - 2983194 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_251327.1
GI 15597833
Affymetrix PA2637_nuoA_at
Entrez 882344
GenBank AAG06025.1
INSDC AAG06025.1
NCBI Locus Tag PA2637
protein_id(GenBank) gb|AAG06025.1|AE004692_4|gnl|PseudoCAP|PA2637
TIGR NTL03PA02637
UniParc UPI00000C577E
UniProtKB Acc Q9I0K1
UniProtKB ID NUOA2_PSEAE
UniRef100 UniRef100_Q02NC9
UniRef50 UniRef50_A6TBX4
UniRef90 UniRef90_Q02NC9

Product

Feature Type CDS
Coding Frame 1
Product Name
NADH dehydrogenase I chain A
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.46
Kyte-Doolittle Hydrophobicity Value 0.606
Molecular Weight (kDa) 15.0
Isoelectric Point (pI) 10.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 426 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002916 (518 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2637
Search term: nuoA

Human Homologs

Ensembl 110, assembly GRCh38.p14
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 [Source:HGNC Symbol;Acc:HGNC:7458]
E-value: 3.7e-05
Percent Identity: 32.1

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.
Weidner U, Geier S, Ptock A, Friedrich T, Leif H, Weiss H
J Mol Biol 1993 Sep 5;233(1):109-22
PubMed ID: 7690854