Pseudomonas aeruginosa PAO1, PA2827

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2827
Name
Synonym: yeaA
Replicon chromosome
Genomic location 3180554 - 3180952 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_251517.1
GI 15598023
Affymetrix PA2827_at
DNASU PaCD00007228
Entrez 878842
GenBank AAG06215.1
INSDC AAG06215.1
NCBI Locus Tag PA2827
protein_id(GenBank) gb|AAG06215.1|AE004709_8|gnl|PseudoCAP|PA2827
TIGR NTL03PA02827
UniParc UPI000012F67C
UniProtKB Acc Q9I016
UniProtKB ID MSRB_PSEAE
UniRef100 UniRef100_B7UUZ9
UniRef50 UniRef50_A6T7R0
UniRef90 UniRef90_A6V3R3

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Charge (pH 7) -3.54
Kyte-Doolittle Hydrophobicity Value -0.582
Molecular Weight (kDa) 14.8
Isoelectric Point (pI) 6.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Drosophila melanogaster
Notes
Infection model Drosophila melanogaster feeding assay
Reference 23687271

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 523 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002740 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2827

Human Homologs

Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9
Ensembl 110, assembly GRCh38.p14
methionine sulfoxide reductase B3 [Source:HGNC Symbol;Acc:HGNC:27375]
E-value: 6.8e-41
Percent Identity: 57.9

References

Gene expression and physiological role of Pseudomonas aeruginosa methionine sulfoxide reductases during oxidative stress.
Romsang A, Atichartpongkul S, Trinachartvanit W, Vattanaviboon P, Mongkolsuk S
J Bacteriol 2013 Aug;195(15):3299-308
PubMed ID: 23687271