Pseudomonas aeruginosa PAO1, PA2981 (lpxK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2981
Name
lpxK
Replicon chromosome
Genomic location 3338679 - 3339677 (- strand)

Cross-References

RefSeq NP_251671.1
GI 15598177
Affymetrix PA2981_lpxK_at
Entrez 880503
GenBank AAG06369.1
INSDC AAG06369.1
NCBI Locus Tag PA2981
protein_id(GenBank) gb|AAG06369.1|AE004723_13|gnl|PseudoCAP|PA2981
TIGR NTL03PA02981
UniParc UPI000012E928
UniProtKB Acc Q9HZM3
UniProtKB ID LPXK_PSEAE
UniRef100 UniRef100_B7V147
UniRef50 UniRef50_Q87YF5
UniRef90 UniRef90_B7V147

Product

Feature Type CDS
Coding Frame 1
Product Name
tetraacyldisaccharide 4*-kinase
Product Name Confidence: Class 2
Synonyms lipid a 4*-kinase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.05
Kyte-Doolittle Hydrophobicity Value -0.119
Molecular Weight (kDa) 36.7
Isoelectric Point (pI) 7.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 346 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002601 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2981
Search term: lpxK

Human Homologs

References

Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene.
Garrett TA, Que NL, Raetz CR
J Biol Chem 1998 May 15;273(20):12457-65
PubMed ID: 9575203