Pseudomonas aeruginosa PAO1, PA3007 (lexA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3007
Name
lexA
Replicon chromosome
Genomic location 3367903 - 3368517 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_251697.1
GI 15598203
Affymetrix PA3007_lexA_at
DNASU PaCD00007327
Entrez 879875
GenBank AAG06395.1
INSDC AAG06395.1
NCBI Locus Tag PA3007
protein_id(GenBank) gb|AAG06395.1|AE004726_1|gnl|PseudoCAP|PA3007
TIGR NTL03PA03007
UniParc UPI000012E5C0
UniProtKB Acc P37452
UniProtKB ID LEXA_PSEAE
UniRef100 UniRef100_B7UYS3
UniRef50 UniRef50_P0A153
UniRef90 UniRef90_A6V389

Product

Feature Type CDS
Coding Frame 1
Product Name
repressor protein LexA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.09
Kyte-Doolittle Hydrophobicity Value -0.215
Molecular Weight (kDa) 22.5
Isoelectric Point (pI) 6.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 472 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002575 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3007
Search term: lexA

Human Homologs

References

Purified lexA protein is a repressor of the recA and lexA genes.
Little JW, Mount DW, Yanisch-Perron CR
Proc Natl Acad Sci U S A 1981 Jul;78(7):4199-203
PubMed ID: 7027255
Nucleotide sequence analysis and comparison of the lexA genes from Salmonella typhimurium, Erwinia carotovora, Pseudomonas aeruginosa and Pseudomonas putida.
Garriga X, Calero S, Barbé J
Mol Gen Genet 1992 Dec;236(1):125-34
PubMed ID: 1494343
Analysis of the DNA damage-mediated induction of Pseudomonas putida and Pseudomonas aeruginosa lexA genes.
Calero S, Garriga X, Barbé J
FEMS Microbiol Lett 1993 Jun 1;110(1):65-70
PubMed ID: 8319897