Pseudomonas aeruginosa PAO1, PA3116

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3116
Name
Replicon chromosome
Genomic location 3498374 - 3499384 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251806.1
GI 15598312
Affymetrix PA3116_at
DNASU PaCD00007370
Entrez 882802
GenBank AAG06504.1
INSDC AAG06504.1
NCBI Locus Tag PA3116
protein_id(GenBank) gb|AAG06504.1|AE004736_1|gnl|PseudoCAP|PA3116
TIGR NTL03PA03116
UniParc UPI0000137E52
UniProtKB Acc O87014
UniProtKB ID USG_PSEAE
UniRef100 UniRef100_O87014
UniRef50 UniRef50_O87014
UniRef90 UniRef90_O87014

Product

Feature Type CDS
Coding Frame 1
Product Name
probable aspartate-semialdehyde dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -14.03
Kyte-Doolittle Hydrophobicity Value 0.317
Molecular Weight (kDa) 35.3
Isoelectric Point (pI) 4.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2HJS STRUCTURAL GENOMICS, UNKNOWN FUNCTION 06/30/06 The structure of a probable aspartate-semialdehyde dehydrogenase from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.2 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 468 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002482 (524 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3116

Human Homologs

References

The sixth and seventh cholera pandemics are due to independent clones separately derived from environmental, nontoxigenic, non-O1 Vibrio cholerae.
Karaolis DK, Lan R, Reeves PR
J Bacteriol 1995 Jun;177(11):3191-8
PubMed ID: 7768818