Pseudomonas aeruginosa PAO1, PA3117 (asd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3117
Name
asd
Replicon chromosome
Genomic location 3499486 - 3500598 (- strand)

Cross-References

RefSeq NP_251807.1
GI 15598313
Affymetrix PA3117_asd_at
Entrez 882803
GenBank AAG06505.1
INSDC AAG06505.1
NCBI Locus Tag PA3117
protein_id(GenBank) gb|AAG06505.1|AE004736_2|gnl|PseudoCAP|PA3117
TIGR NTL03PA03117
UniParc UPI00001292B1
UniProtKB Acc Q51344
UniProtKB ID DHAS_PSEAE
UniRef100 UniRef100_Q51344
UniRef50 UniRef50_P44801
UniRef90 UniRef90_Q51344

Product

Feature Type CDS
Coding Frame 1
Product Name
aspartate semialdehyde dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.91
Kyte-Doolittle Hydrophobicity Value -0.071
Molecular Weight (kDa) 40.5
Isoelectric Point (pI) 5.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5BNT OXIDOREDUCTASE 05/26/15 X-ray Crystal Structure of a Aspartate-semialdehyde dehydrogenase bound to NADP from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 530 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002481 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3117
Search term: asd

Human Homologs

References

Identification of an essential cysteine in the reaction catalyzed by aspartate-beta-semialdehyde dehydrogenase from Escherichia coli.
Karsten WE, Viola RE
Biochim Biophys Acta 1992 May 22;1121(1-2):234-8
PubMed ID: 1350921
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994