Pseudomonas aeruginosa PAO1, PA3629 (adhC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3629
Name
adhC
Replicon chromosome
Genomic location 4063875 - 4064987 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252319.1
GI 15598825
Affymetrix PA3629_adhC_at
DNASU PaCD00007591
Entrez 880459
GenBank AAG07017.1
INSDC AAG07017.1
NCBI Locus Tag PA3629
protein_id(GenBank) gb|AAG07017.1|AE004783_2|gnl|PseudoCAP|PA3629
TIGR NTL03PA03629
UniParc UPI00000C5A9B
UniProtKB Acc Q9HY01
UniProtKB ID Q9HY01_PSEAE
UniRef100 UniRef100_Q9HY01
UniRef50 UniRef50_P46415
UniRef90 UniRef90_Q9HY01

Product

Feature Type CDS
Coding Frame 1
Product Name
alcohol dehydrogenase class III
Product Name Confidence: Class 2
Synonyms glutathione-dependent formaldehyde dehydrogenase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.43
Kyte-Doolittle Hydrophobicity Value 0.134
Molecular Weight (kDa) 39.2
Isoelectric Point (pI) 5.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 561 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002045 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3629
Search term: adhC

Human Homologs

Ensembl 110, assembly GRCh38.p14
alcohol dehydrogenase 5 (class III), chi polypeptide [Source:HGNC Symbol;Acc:HGNC:253]
E-value: 6.4e-145
Percent Identity: 64.7

References

Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: a class III alcohol dehydrogenase.
Gutheil WG, Holmquist B, Vallee BL
Biochemistry 1992 Jan 21;31(2):475-81
PubMed ID: 1731906