Pseudomonas aeruginosa PAO1, PA3645 (fabZ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3645
Name
fabZ
Synonym: sefA
Replicon chromosome
Genomic location 4082958 - 4083398 (- strand)

Cross-References

RefSeq NP_252335.1
GI 15598841
Affymetrix PA3645_fabZ_at
DNASU PaCD00007598
Entrez 880494
GenBank AAG07033.1
INSDC AAG07033.1
NCBI Locus Tag PA3645
protein_id(GenBank) gb|AAG07033.1|AE004784_6|gnl|PseudoCAP|PA3645
TIGR NTL03PA03645
UniParc UPI000012A4B1
UniProtKB Acc Q9HXY7
UniProtKB ID FABZ_PSEAE
UniRef100 UniRef100_A6V1E3
UniRef50 UniRef50_Q1H150
UniRef90 UniRef90_A6V1E3

Product

Feature Type CDS
Coding Frame 1
Product Name
(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.10
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 16.8
Isoelectric Point (pI) 7.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1U1Z LYASE 07/16/04 The Structure of (3R)-hydroxyacyl-ACP dehydratase (FabZ) Pseudomonas aeruginosa 2.5 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 505 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002029 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3645
Search term: fabZ

Human Homologs

References

An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis.
Mohan S, Kelly TM, Eveland SS, Raetz CR, Anderson MS
J Biol Chem 1994 Dec 30;269(52):32896-903
PubMed ID: 7806516
Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site.
Leesong M, Henderson BS, Gillig JR, Schwab JM, Smith JL
Structure 1996 Mar 15;4(3):253-64
PubMed ID: 8805534