Pseudomonas aeruginosa PAO1, PA3650 (dxr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3650
Name
dxr
Synonym: yaeM
Replicon chromosome
Genomic location 4088904 - 4090094 (- strand)

Cross-References

RefSeq NP_252340.1
GI 15598846
Affymetrix PA3650_dxr_at
Entrez 880464
GenBank AAG07038.1
NCBI Locus Tag PA3650
protein_id(GenBank) gb|AAG07038.1|AE004785_2|gnl|PseudoCAP|PA3650
TIGR NTL03PA03650
UniProtKB Acc Q9KGU6
UniProtKB ID DXR_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
1-deoxy-d-xylulose 5-phosphate reductoisomerase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.21
Kyte-Doolittle Hydrophobicity Value 0.147
Molecular Weight (kDa) 42.5
Isoelectric Point (pI) 5.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 507 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002024 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3650
Search term: dxr

Human Homologs

References

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.
Takahashi S, Kuzuyama T, Watanabe H, Seto H
Proc Natl Acad Sci U S A 1998 Aug 18;95(17):9879-84
PubMed ID: 9707569