Pseudomonas aeruginosa PAO1, PA3813 (iscU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3813
Name
iscU
Replicon chromosome
Genomic location 4270499 - 4270885 (- strand)

Cross-References

RefSeq NP_252502.1
GI 15599008
Affymetrix PA3813_iscU_at
DNASU PaCD00007661
Entrez 879917
GenBank AAG07200.1
INSDC AAG07200.1
NCBI Locus Tag PA3813
protein_id(GenBank) gb|AAG07200.1|AE004799_6|gnl|PseudoCAP|PA3813
TIGR NTL03PA03813
UniParc UPI00000C5B22
UniProtKB Acc Q9HXI9
UniProtKB ID Q9HXI9_PSEAE
UniRef100 UniRef100_W0YVM8
UniRef50 UniRef50_O31270
UniRef90 UniRef90_O31270

Product

Feature Type CDS
Coding Frame 1
Product Name
probable iron-binding protein IscU
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.62
Kyte-Doolittle Hydrophobicity Value -0.238
Molecular Weight (kDa) 13.8
Isoelectric Point (pI) 5.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 425 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001853 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3813
Search term: iscU

Human Homologs

Ensembl 110, assembly GRCh38.p14
iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882]
E-value: 4.6e-50
Percent Identity: 75.6

References

Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii.
Zheng L, Cash VL, Flint DH, Dean DR
J Biol Chem 1998 May 22;273(21):13264-72
PubMed ID: 9582371