Pseudomonas aeruginosa PAO1, PA3905 (tecT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3905
Name
tecT
Replicon chromosome
Genomic location 4374330 - 4374857 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
CommentPAAR4, TecT and co-TecT are required for TseT-mediated killing.
CommentTecT and co-TecT form a complex that dissociates upon PAAR4 binding to TecT.

Cross-References

RefSeq NP_252594.1
GI 15599100
Affymetrix PA3905_at
DNASU PaCD00007703
Entrez 878951
GenBank AAG07292.1
INSDC AAG07292.1
NCBI Locus Tag PA3905
protein_id(GenBank) gb|AAG07292.1|AE004808_2|gnl|PseudoCAP|PA3905
TIGR NTL03PA03905
UniParc UPI00000C5B6B
UniProtKB Acc Q9HXA8
UniProtKB ID Q9HXA8_PSEAE
UniRef100 UniRef100_W0YYY0
UniRef50 UniRef50_Q02S71
UniRef90 UniRef90_Q02S71

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI effector chaperone for Tox-Rease, TecT
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.48
Kyte-Doolittle Hydrophobicity Value -0.337
Molecular Weight (kDa) 20.0
Isoelectric Point (pI) 7.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 12 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001771 (309 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3905
Search term: tecT

Human Homologs

References

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone-co-chaperone complex.
Burkinshaw BJ, Liang X, Wong M, Le ANH, Lam L, Dong TG
Nat Microbiol 2018 May;3(5):632-640
PubMed ID: 29632369