Pseudomonas aeruginosa PAO1, PA3909 (eddB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3909
Name
eddB
Replicon chromosome
Genomic location 4377311 - 4379650 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs
Comment

Cross-References

RefSeq NP_252598.1
GI 15599104
Affymetrix PA3909_at
Entrez 878966
GenBank AAG07296.1
INSDC AAG07296.1
NCBI Locus Tag PA3909
protein_id(GenBank) gb|AAG07296.1|AE004808_6|gnl|PseudoCAP|PA3909
TIGR NTL03PA03909
UniParc UPI00000C5B6F
UniProtKB Acc Q9HXA4
UniProtKB ID Q9HXA4_PSEAE
UniRef100 UniRef100_Q9HXA4
UniRef50 UniRef50_Q9HXA4
UniRef90 UniRef90_Q9HXA4

Product

Feature Type CDS
Coding Frame 1
Product Name
Extracelullar DNA degradation protein, EddB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -19.09
Kyte-Doolittle Hydrophobicity Value -0.336
Molecular Weight (kDa) 83.1
Isoelectric Point (pI) 4.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 149 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001767 (301 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3909
Search term: eddB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient source.
Mulcahy H, Charron-Mazenod L, Lewenza S
Environ Microbiol 2010 Jun;12(6):1621-9
PubMed ID: 20370819
Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.
Lewenza S, Falsafi RK, Winsor G, Gooderham WJ, McPhee JB, Brinkman FS, Hancock RE
Genome Res 2005 Apr;15(4):583-9
PubMed ID: 15805499
Secreted Phosphatase and Deoxyribonuclease Are Required by Pseudomonas aeruginosa To Defend against Neutrophil Extracellular Traps.
Wilton M, Halverson TWR, Charron-Mazenod L, Parkins MD, Lewenza S
Infect Immun 2018 Sep;86(9)
PubMed ID: 29967090