Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3920
|
Name |
copA1
Synonym: yvgX Synonym: cueA |
Replicon | chromosome |
Genomic location | 4389231 - 4391609 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | PA3920 later referred to as CopA1 i in order to align with naming and homologies (PMID:28760827, PMID:21091508). |
Comment | PA3920 was originally identified as cueA in 2005 where its role in Cu resistance/tolerance was confirmed (PMID:16128398). Referred to as cueA in 2010 where role in Cu tolerance was also confirmed (PMID: 20233934). |
RefSeq | NP_252609.1 |
GI | 15599115 |
Affymetrix | PA3920_at |
Entrez | 879022 |
GenBank | AAG07307.1 |
INSDC | AAG07307.1 |
NCBI Locus Tag | PA3920 |
protein_id(GenBank) | gb|AAG07307.1|AE004809_7|gnl|PseudoCAP|PA3920 |
TIGR | NTL03PA03920 |
UniParc | UPI00000C5B78 |
UniProtKB Acc | Q9HX93 |
UniProtKB ID | Q9HX93_PSEAE |
UniRef100 | UniRef100_S0J2Y1 |
UniRef50 | UniRef50_A0A022P3W0 |
UniRef90 | UniRef90_A0A022P3W0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
CopA1
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -1.04 |
Kyte-Doolittle Hydrophobicity Value | 0.255 |
Molecular Weight (kDa) | 83.4 |
Isoelectric Point (pI) | 6.85 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 643 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001754 (534 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3920
Search term: copA1
Search term: CopA1
|
Ensembl
110, assembly
GRCh38.p14
|
ATPase copper transporting beta [Source:HGNC Symbol;Acc:HGNC:870]
E-value:
5.0e-115
Percent Identity:
36.9
|
Ensembl
110, assembly
GRCh38.p14
|
ATPase copper transporting beta [Source:HGNC Symbol;Acc:HGNC:870]
E-value:
5.0e-115
Percent Identity:
36.9
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
Mutations in the cueA gene encoding a copper homeostasis P-type ATPase reduce the pathogenicity of Pseudomonas aeruginosa in mice.
Schwan WR, Warrener P, Keunz E, Stover CK, Folger KR
Int J Med Microbiol 2005 Aug;295(4):237-42
PubMed ID: 16128398
|
Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa.
Thaden JT, Lory S, Gardner TS
J Bacteriol 2010 May;192(10):2557-68
PubMed ID: 20233934
|
Copper homeostasis networks in the bacterium Pseudomonas aeruginosa.
Quintana J, Novoa-Aponte L, Argüello JM
J Biol Chem 2017 Sep 22;292(38):15691-15704
PubMed ID: 28760827
|
Distinct functional roles of homologous Cu+ efflux ATPases in Pseudomonas aeruginosa.
González-Guerrero M, Raimunda D, Cheng X, Argüello JM
Mol Microbiol 2010 Dec;78(5):1246-58
PubMed ID: 21091508
|