Pseudomonas aeruginosa PAO1, PA4054 (ribB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4054
Name
ribB
Synonym: ribA
Replicon chromosome
Genomic location 4534710 - 4535807 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252743.1
GI 15599249
Affymetrix PA4054_ribB_at
Entrez 878914
GenBank AAG07441.1
INSDC AAG07441.1
NCBI Locus Tag PA4054
protein_id(GenBank) gb|AAG07441.1|AE004822_1|gnl|PseudoCAP|PA4054
TIGR NTL03PA04054
UniParc UPI00000C5BE1
UniProtKB Acc Q9HWX4
UniProtKB ID RIBB_PSEAE
UniRef100 UniRef100_Q9HWX4
UniRef50 UniRef50_Q9HWX4
UniRef90 UniRef90_Q9HWX4

Product

Feature Type CDS
Coding Frame 1
Product Name
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -12.52
Kyte-Doolittle Hydrophobicity Value -0.017
Molecular Weight (kDa) 39.4
Isoelectric Point (pI) 5.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001630 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4054
Search term: ribB

Human Homologs

References

Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli.
Richter G, Ritz H, Katzenmeier G, Volk R, Kohnle A, Lottspeich F, Allendorf D, Bacher A
J Bacteriol 1993 Jul;175(13):4045-51
PubMed ID: 8320220
Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum.
Lee CY, O'Kane DJ, Meighen EA
J Bacteriol 1994 Apr;176(7):2100-4
PubMed ID: 8144477