Pseudomonas aeruginosa PAO1, PA4092 (hpaC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4092
Name
hpaC
Replicon chromosome
Genomic location 4575332 - 4575844 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252781.1
GI 15599287
Affymetrix PA4092_hpaC_at
DNASU PaCD00007788
Entrez 878735
GenBank AAG07479.1
INSDC AAG07479.1
NCBI Locus Tag PA4092
protein_id(GenBank) gb|AAG07479.1|AE004825_8|gnl|PseudoCAP|PA4092
TIGR NTL03PA04092
UniParc UPI00000C5C06
UniProtKB Acc Q9HWT6
UniProtKB ID Q9HWT6_PSEAE
UniRef100 UniRef100_Q9HWT6
UniRef50 UniRef50_A0A068QSC3
UniRef90 UniRef90_A6V007

Product

Feature Type CDS
Coding Frame 1
Product Name
4-hydroxyphenylacetate 3-monooxygenase small chain
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -0.48
Kyte-Doolittle Hydrophobicity Value -0.055
Molecular Weight (kDa) 18.6
Isoelectric Point (pI) 6.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 246 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001599 (392 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4092
Search term: hpaC

Human Homologs

References

Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
Prieto MA, Garcia JL
J Biol Chem 1994 Sep 9;269(36):22823-9
PubMed ID: 8077235
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
Prieto MA, Díaz E, García JL
J Bacteriol 1996 Jan;178(1):111-20
PubMed ID: 8550403
Identification of a novel positive regulator of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
Prieto MA, García JL
Biochem Biophys Res Commun 1997 Mar 27;232(3):759-65
PubMed ID: 9126350