Pseudomonas aeruginosa PAO1, PA4280 (birA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4280
Name
birA
Replicon chromosome
Genomic location 4787477 - 4788415 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252970.1
GI 15599476
Affymetrix PA4280_birA_at
DNASU PaCD00007860
Entrez 881668
GenBank AAG07668.1
INSDC AAG07668.1
NCBI Locus Tag PA4280
protein_id(GenBank) gb|AAG07668.1|AE004843_10|gnl|PseudoCAP|PA4280
TIGR NTL03PA04281
UniParc UPI00000C5C92
UniProtKB Acc Q9HWC0
UniProtKB ID Q9HWC0_PSEAE
UniRef100 UniRef100_Q9HWC0
UniRef50 UniRef50_Q4K518
UniRef90 UniRef90_Q9HWC0

Product

Feature Type CDS
Coding Frame 1
Product Name
BirA bifunctional protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.39
Kyte-Doolittle Hydrophobicity Value -0.125
Molecular Weight (kDa) 34.0
Isoelectric Point (pI) 7.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001431 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4280
Search term: birA

Human Homologs

References

DNA-binding and enzymatic domains of the bifunctional biotin operon repressor (BirA) of Escherichia coli.
Buoncristiani MR, Howard PK, Otsuka AJ
Gene 1986;44(2-3):255-61
PubMed ID: 3536662
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
Wilson KP, Shewchuk LM, Brennan RG, Otsuka AJ, Matthews BW
Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9257-61
PubMed ID: 1409631