Pseudomonas aeruginosa PAO1, PA4315 (mvaT)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
| Locus Tag |
PA4315
|
| Name |
mvaT
|
| Replicon | chromosome |
| Genomic location | 4843812 - 4844186 (+ strand) |
| Transposon Mutants | 4 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_253005.1 |
| GI | 15599511 |
| Affymetrix | PA4315_mvaT_at |
| Entrez | 881542 |
| GenBank | AAG07703.1 |
| INSDC | AAP33788.1 |
| NCBI Locus Tag | PA4315 |
| protein_id(GenBank) | gb|AAG07703.1|AE004848_2|gnl|PseudoCAP|PA4315 |
| TIGR | NTL03PA04316 |
| UniParc | UPI00000C5CB3 |
| UniProtKB Acc | Q9HW86 |
| UniProtKB Acc | Q79J93 |
| UniProtKB ID | Q9HW86_PSEAE |
| UniProtKB ID | Q9HW86_PSEAE |
| UniRef100 | UniRef100_Q9HW86 |
| UniRef50 | UniRef50_Q9HW86 |
| UniRef90 | UniRef90_Q9HW86 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
transcriptional regulator MvaT, P16 subunit
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | 6.47 |
| Kyte-Doolittle Hydrophobicity Value | -0.941 |
| Molecular Weight (kDa) | 14.2 |
| Isoelectric Point (pI) | 10.14 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
| Look for predicted 3D structure in AlphaFold DB: Search |
| Look for predicted 3D structure in AlphaFold DB: Search |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2MXE | TRANSCRIPTION REGULATOR | 12/25/14 | Solution structure of the C-terminal domain of MvaT | Pseudomonas aeruginosa PAO1 | NOT | SOLUTION NMR | 100.0 |
| 2MXF | TRANSCRIPTION REGULATOR/DNA | 12/30/14 | Structure of the DNA complex of the C-Terminal domain of MvaT | Pseudomonas aeruginosa PAO1; SYNTHETIC CONSTRUCT | NOT | SOLUTION NMR | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003913 (536 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA4315
Search term: mvaT
Search term: transcriptional regulator MvaT, P16 subunit
|
Human Homologs
References
|
The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression.
Westfall LW, Luna AM, Francisco MS, Diggle SP, Worrall KE, Williams P, Cámara M, Hamood AN
Microbiology (Reading) 2004 Nov;150(Pt 11):3797-3806
PubMed ID: 15528665
|
|
The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1.
Li C, Wally H, Miller SJ, Lu CD
J Bacteriol 2009 Oct;191(20):6211-8
PubMed ID: 19684136
|