Pseudomonas aeruginosa PAO1, PA4400 (mutT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4400
Name
mutT
Replicon chromosome
Genomic location 4930748 - 4931695 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253090.1
GI 15599596
Affymetrix PA4400_at
Entrez 881318
GenBank AAG07788.1
INSDC AAG07788.1
NCBI Locus Tag PA4400
protein_id(GenBank) gb|AAG07788.1|AE004855_10|gnl|PseudoCAP|PA4400
TIGR NTL03PA04401
UniParc UPI00000C5CFE
UniProtKB Acc Q9HW06
UniProtKB ID Q9HW06_PSEAE
UniRef100 UniRef100_S0I3E9
UniRef50 UniRef50_D7I481
UniRef90 UniRef90_A0A077JML3

Product

Feature Type CDS
Coding Frame 1
Product Name
probable pyrophosphohydrolase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.64
Kyte-Doolittle Hydrophobicity Value -0.169
Molecular Weight (kDa) 34.0
Isoelectric Point (pI) 5.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 441 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003990 (550 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4400
Search term: mutT

Human Homologs

References

Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion.
Akiyama M, Horiuchi T, Sekiguchi M
Mol Gen Genet 1987 Jan;206(1):9-16
PubMed ID: 3033442
Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase.
Bhatnagar SK, Bessman MJ
J Biol Chem 1988 Jun 25;263(18):8953-7
PubMed ID: 3288626
Characterization of the mutT nucleoside triphosphatase of Escherichia coli.
Bhatnagar SK, Bullions LC, Bessman MJ
J Biol Chem 1991 May 15;266(14):9050-4
PubMed ID: 1851162
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.
Maki H, Sekiguchi M
Nature 1992 Jan 16;355(6357):273-5
PubMed ID: 1309939
A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.
Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T
DNA Res. 1996 Dec;3(6):363-77
PubMed ID: 9097039
Characterization of the GO system of Pseudomonas aeruginosa.
Oliver A, Sánchez JM, Blázquez J
FEMS Microbiol. Lett. 2002 Nov;217(1):31-5
PubMed ID: 12445642