Pseudomonas aeruginosa PAO1, PA4506 (dppF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4506
Name
dppF
Replicon chromosome
Genomic location 5045028 - 5045999 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253196.1
GI 15599702
Affymetrix PA4506_at
Entrez 881159
GenBank AAG07894.1
INSDC AAG07894.1
NCBI Locus Tag PA4506
protein_id(GenBank) gb|AAG07894.1|AE004864_6|gnl|PseudoCAP|PA4506
TIGR NTL03PA04507
UniParc UPI00000C5D42
UniProtKB Acc Q9HVR5
UniProtKB ID Q9HVR5_PSEAE
UniRef100 UniRef100_W0YZ53
UniRef50 UniRef50_U4KA71
UniRef90 UniRef90_W0YZ53

Product

Feature Type CDS
Coding Frame 1
Product Name
dipeptide ABC transporter ATP-binding protein DppF
Product Name Confidence: Class 1
Synonyms probable ATP-binding component of ABC dipeptide transporter
Evidence for Translation
Detected using LC-MS/MS (36.34 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 10.49
Kyte-Doolittle Hydrophobicity Value -0.416
Molecular Weight (kDa) 36.3
Isoelectric Point (pI) 9.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004093 (513 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4506
Search term: dppF

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 7 [Source:HGNC Symbol;Acc:HGNC:48]
E-value: 1.5e-20
Percent Identity: 33.8

References

Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
Pletzer D, Lafon C, Braun Y, Köhler T, Page MG, Mourez M, Weingart H
PLoS One 2014;9(10):e111311
PubMed ID: 25338022