Pseudomonas aeruginosa PAO1, PA4547 (pilR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4547
Name
pilR
Replicon chromosome
Genomic location 5094985 - 5096322 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253237.1
GI 15599743
Affymetrix PA4547_pilR_at
Entrez 877622
GenBank AAG07935.1
INSDC AAG07935.1
NCBI Locus Tag PA4547
protein_id(GenBank) gb|AAG07935.1|AE004868_6|gnl|PseudoCAP|PA4547
TIGR NTL03PA04548
UniParc UPI0000131ACE
UniProtKB Acc Q00934
UniProtKB ID PILR_PSEAE
UniRef100 UniRef100_Q00934
UniRef50 UniRef50_Q00934
UniRef90 UniRef90_Q00934

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator PilR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.88
Kyte-Doolittle Hydrophobicity Value -0.360
Molecular Weight (kDa) 49.7
Isoelectric Point (pI) 5.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0082
Category Type IV pili biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004209 (486 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4547
Search term: pilR

Human Homologs

References

Dual function of PilS during transcriptional activation of the Pseudomonas aeruginosa pilin subunit gene.
Boyd JM, Lory S
J Bacteriol 1996 Feb;178(3):831-9
PubMed ID: 8550520