Pseudomonas aeruginosa PAO1, PA4693 (pssA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4693
Name
pssA
Replicon chromosome
Genomic location 5271485 - 5272300 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_253381.1
GI 15599887
Affymetrix PA4693_pssA_at
Entrez 881482
GenBank AAG08079.1
INSDC AAG08079.1
NCBI Locus Tag PA4693
protein_id(GenBank) gb|AAG08079.1|AE004883_3|gnl|PseudoCAP|PA4693
TIGR NTL03PA04694
UniParc UPI00000C5DCA
UniProtKB Acc Q9HVA3
UniProtKB ID Q9HVA3_PSEAE
UniRef100 UniRef100_Q9HVA3
UniRef50 UniRef50_M5CUF4
UniRef90 UniRef90_Q9HVA3

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphatidylserine synthase
Product Name Confidence: Class 2
Synonyms CDP-diacylglycerol--serine O-phosphatidyltransferase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.95
Kyte-Doolittle Hydrophobicity Value 0.483
Molecular Weight (kDa) 29.3
Isoelectric Point (pI) 7.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 390 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004342 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4693
Search term: pssA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The Helicobacter pylori gene encoding phosphatidylserine synthase: sequence, expression, and insertional mutagenesis.
Ge Z, Taylor DE
J Bacteriol 1997 Aug;179(16):4970-6
PubMed ID: 9260935