Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4694
|
Name |
ilvC
|
Replicon | chromosome |
Genomic location | 5272455 - 5273471 (- strand) |
Transposon Mutants | 4 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_253382.1 |
GI | 15599888 |
Affymetrix | PA4694_ilvC_at |
Entrez | 881483 |
GenBank | AAG08080.1 |
INSDC | AAG08080.1 |
NCBI Locus Tag | PA4694 |
protein_id(GenBank) | gb|AAG08080.1|AE004883_4|gnl|PseudoCAP|PA4694 |
TIGR | NTL03PA04695 |
UniParc | UPI000012D557 |
UniProtKB Acc | Q9HVA2 |
UniProtKB ID | ILVC_PSEAE |
UniRef100 | UniRef100_B7V1A6 |
UniRef50 | UniRef50_Q9RU74 |
UniRef90 | UniRef90_Q888N4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
ketol-acid reductoisomerase
|
Synonyms |
alpha-keto-beta-hydroxylacil reductoisomerase acetohydroxy-acid isomeroreductase |
Evidence for Translation |
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -6.26 |
Kyte-Doolittle Hydrophobicity Value | -0.092 |
Molecular Weight (kDa) | 36.4 |
Isoelectric Point (pI) | 5.65 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4XIY | OXIDOREDUCTASE | 01/07/15 | Crystal structure of ketol-acid reductoisomerase from Azotobacter | Azotobacter vinelandii | 2.5 | X-RAY DIFFRACTION | 93.2 |
1NP3 | OXIDOREDUCTASE | 01/17/03 | Crystal structure of class I acetohydroxy acid isomeroreductase from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004343 (537 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4694
Search term: ilvC
Search term: ketol-acid reductoisomerase
|
Mechanism of ketol acid reductoisomerase--steady-state analysis and metal ion requirement.
Chunduru SK, Mrachko GT, Calvo KC
Biochemistry 1989 Jan 24;28(2):486-93
PubMed ID: 2653423
|
Structure and expression of a cyanobacterial ilvC gene encoding acetohydroxyacid isomeroreductase.
Rieble S, Beale SI
J Bacteriol 1992 Dec;174(24):7910-8
PubMed ID: 1459938
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|