Pseudomonas aeruginosa PAO1, PA4749 (glmM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4749
Name
glmM
Synonym: yhbF
Synonym: mrsA
Replicon chromosome
Genomic location 5333567 - 5334904 (- strand)

Cross-References

RefSeq NP_253437.1
GI 15599943
Affymetrix PA4749_glmM_at
Entrez 881713
GenBank AAG08135.1
INSDC AAG08135.1
NCBI Locus Tag PA4749
protein_id(GenBank) gb|AAG08135.1|AE004888_10|gnl|PseudoCAP|PA4749
TIGR NTL03PA04750
UniParc UPI00000C5DF0
UniProtKB Acc Q9HV50
UniProtKB ID GLMM_PSEAE
UniRef100 UniRef100_Q02FS3
UniRef50 UniRef50_P45164
UniRef90 UniRef90_Q02FS3

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoglucosamine mutase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.34
Kyte-Doolittle Hydrophobicity Value -0.024
Molecular Weight (kDa) 47.8
Isoelectric Point (pI) 5.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 658 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004394 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4749
Search term: glmM

Human Homologs

Ensembl 110, assembly GRCh38.p14
phosphoglucomutase 1 [Source:HGNC Symbol;Acc:HGNC:8905]
E-value: 1.7e-11
Percent Identity: 26.0

References

Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutase.
Tavares IM, Jolly L, Pompeo F, Leitão JH, Fialho AM, Sá-Correia I, Mengin-Lecreulx D
J Bacteriol 2000 Aug;182(16):4453-7
PubMed ID: 10913078
The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome.
Dallas WS, Dev IK, Ray PH
J Bacteriol 1993 Dec;175(23):7743-4
PubMed ID: 8244950
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
Mengin-Lecreulx D, van Heijenoort J
J Biol Chem 1996 Jan 5;271(1):32-9
PubMed ID: 8550580