Pseudomonas aeruginosa PAO1, PA4752 (ftsJ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4752
Name
ftsJ
Replicon chromosome
Genomic location 5337900 - 5338523 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253440.1
GI 15599946
Affymetrix PA4752_ftsJ_at
Entrez 881725
GenBank AAG08138.1
INSDC AAB39254.1
NCBI Locus Tag PA4752
protein_id(GenBank) gb|AAG08138.1|AE004889_1|gnl|PseudoCAP|PA4752
TIGR NTL03PA04753
UniParc UPI0000134A56
UniProtKB Acc P95454
UniProtKB ID RLME_PSEAE
UniRef100 UniRef100_B7V1G4
UniRef50 UniRef50_Q47YJ3
UniRef90 UniRef90_A4XYE8

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsJ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.69
Kyte-Doolittle Hydrophobicity Value -0.427
Molecular Weight (kDa) 23.5
Isoelectric Point (pI) 7.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 299 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004397 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4752
Search term: ftsJ

Human Homologs

Ensembl 110, assembly GRCh38.p14
mitochondrial rRNA methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16352]
E-value: 1.1e-34
Percent Identity: 37.1
Ensembl 110, assembly GRCh38.p14
mitochondrial rRNA methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16352]
E-value: 1.1e-34
Percent Identity: 37.1

References

Structure and function of the ftsH gene in Escherichia coli.
Ogura T, Tomoyasu T, Yuki T, Morimura S, Begg KJ, Donachie WD, Mori H, Niki H, Hiraga S
Res Microbiol 1991 Feb-Apr;142(2-3):279-82
PubMed ID: 1925026
The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.
Tomoyasu T, Yuki T, Morimura S, Mori H, Yamanaka K, Niki H, Hiraga S, Ogura T
J Bacteriol 1993 Mar;175(5):1344-51
PubMed ID: 8444796