Pseudomonas aeruginosa PAO1, PA4770 (lldP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4770
Name
lldP
Synonym: lctP
Replicon chromosome
Genomic location 5355387 - 5357075 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253458.1
GI 15599964
Affymetrix PA4770_lldP_at
Entrez 881808
GenBank AAG08156.1
INSDC AAG08156.1
NCBI Locus Tag PA4770
protein_id(GenBank) gb|AAG08156.1|AE004890_9|gnl|PseudoCAP|PA4770
TIGR NTL03PA04771
UniParc UPI00000C5DF7
UniProtKB Acc Q9HV38
UniProtKB ID Q9HV38_PSEAE
UniRef100 UniRef100_Q9HV38
UniRef50 UniRef50_P33231
UniRef90 UniRef90_Q9HV38

Product

Feature Type CDS
Coding Frame 1
Product Name
L-lactate permease
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.37
Kyte-Doolittle Hydrophobicity Value 0.956
Molecular Weight (kDa) 58.7
Isoelectric Point (pI) 9.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 251 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004413 (516 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4770
Search term: lldP

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Three overlapping lct genes involved in L-lactate utilization by Escherichia coli.
Dong JM, Taylor JS, Latour DJ, Iuchi S, Lin EC
J Bacteriol 1993 Oct;175(20):6671-8
PubMed ID: 8407843