Pseudomonas aeruginosa PAO1, PA4808 (selA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4808
Name
selA
Synonym: fdhA
Replicon chromosome
Genomic location 5394445 - 5395851 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253496.1
GI 15600002
Affymetrix PA4808_selA_at
Entrez 880198
GenBank AAG08194.1
INSDC AAG08194.1
NCBI Locus Tag PA4808
protein_id(GenBank) gb|AAG08194.1|AE004893_12|gnl|PseudoCAP|PA4808
TIGR NTL03PA04809
UniParc UPI000013581D
UniProtKB Acc Q9HV01
UniProtKB ID SELA_PSEAE
UniRef100 UniRef100_Q9HV01
UniRef50 UniRef50_B7L708
UniRef90 UniRef90_Q9HV01

Product

Feature Type CDS
Coding Frame 1
Product Name
L-seryl-tRNA(ser) selenium transferase
Product Name Confidence: Class 2
Synonyms cysteinyl-tRNA(ser) selenium transferase
selenocysteine synthase, selenocysteinyl-trna(sec) synthase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.16
Kyte-Doolittle Hydrophobicity Value -0.022
Molecular Weight (kDa) 50.3
Isoelectric Point (pI) 9.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 211 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004444 (429 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4808
Search term: selA

Human Homologs

References

Selenocysteine synthase from Escherichia coli. Nucleotide sequence of the gene (selA) and purification of the protein.
Forchhammer K, Leinfelder W, Boesmiller K, Veprek B, Böck A
J Biol Chem 1991 Apr 5;266(10):6318-23
PubMed ID: 2007584
Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence.
Forchhammer K, Böck A
J Biol Chem 1991 Apr 5;266(10):6324-8
PubMed ID: 2007585
The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine.
Forchhammer K, Boesmiller K, Böck A
Biochimie 1991 Dec;73(12):1481-6
PubMed ID: 1839607
Structure of selenocysteine synthase from Escherichia coli and location of tRNA in the seryl-tRNA(sec)-enzyme complex.
Engelhardt H, Forchhammer K, Müller S, Goldie KN, Böck A
Mol Microbiol 1992 Dec;6(23):3461-7
PubMed ID: 1474891