Pseudomonas aeruginosa PAO1, PA4810 (fdnI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4810
Name
fdnI
Synonym: fdhI
Replicon chromosome
Genomic location 5396992 - 5397618 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253498.1
GI 15600004
Affymetrix PA4810_fdnI_at
DNASU PaCD00008089
Entrez 880192
GenBank AAG08196.1
INSDC AAG08196.1
NCBI Locus Tag PA4810
protein_id(GenBank) gb|AAG08196.1|AE004894_2|gnl|PseudoCAP|PA4810
TIGR NTL03PA04811
UniParc UPI00000C5E18
UniProtKB Acc Q9HUZ9
UniProtKB ID Q9HUZ9_PSEAE
UniRef100 UniRef100_W0Z006
UniRef50 UniRef50_G0AI70
UniRef90 UniRef90_A6VCR5

Product

Feature Type CDS
Coding Frame 1
Product Name
nitrate-inducible formate dehydrogenase, gamma subunit
Product Name Confidence: Class 2
Synonyms formate dehydrogenase cytochrome b556 subunit
Evidence for Translation
Charge (pH 7) 12.39
Kyte-Doolittle Hydrophobicity Value 0.313
Molecular Weight (kDa) 23.9
Isoelectric Point (pI) 10.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 141 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004446 (789 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4810
Search term: fdnI

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli.
Enoch HG, Lester RL
J Biol Chem 1975 Sep 10;250(17):6693-705
PubMed ID: 1099093
Purification and properties of formate dehydrogenase from Pseudomonas aeruginosa. Characterization of haem and iron-sulphur centres by magnetic-circular-dichroism and electron-paramagnetic-resonance spectroscopy.
Godfrey C, Coddington A, Greenwood C, Thomson AJ, Gadsby PM
Biochem J 1987 Apr 1;243(1):225-33
PubMed ID: 3038081
Purification and properties of formate dehydrogenase from Pseudomonas aeruginosa. Electron-paramagnetic-resonance studies on the molybdenum centre.
Gadsby PM, Greenwood C, Coddington A, Thomson AJ, Godfrey C
Biochem J 1987 Apr 1;243(1):235-9
PubMed ID: 3038082
Electron-paramagnetic-resonance and magnetic-circular-dichroism studies on the formate dehydrogenase-nitrate reductase particle from Pseudomonas aeruginosa.
Godfrey C, Gadsby PM, Thomson AJ, Greenwood C, Coddington A
Biochem J 1987 Apr 1;243(1):241-8
PubMed ID: 3038083
Nitrate-inducible formate dehydrogenase in Escherichia coli K-12. I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine.
Berg BL, Li J, Heider J, Stewart V
J Biol Chem 1991 Nov 25;266(33):22380-5
PubMed ID: 1834669
Expression and characterization of the Escherichia coli fdo locus and a possible physiological role for aerobic formate dehydrogenase.
Abaibou H, Pommier J, Benoit S, Giordano G, Mandrand-Berthelot MA
J Bacteriol 1995 Dec;177(24):7141-9
PubMed ID: 8522521