Pseudomonas aeruginosa PAO1, PA4844 (ctpL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4844
Name
ctpL
Replicon chromosome
Genomic location 5437785 - 5439758 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253531.1
GI 15600037
Affymetrix PA4844_at
Entrez 879569
GenBank AAG08229.1
INSDC AAG08229.1
NCBI Locus Tag PA4844
protein_id(GenBank) gb|AAG08229.1|AE004897_7|gnl|PseudoCAP|PA4844
TIGR NTL03PA04845
UniParc UPI00000C5E38
UniProtKB Acc Q9HUW6
UniProtKB ID CTPL_PSEAE
UniRef100 UniRef100_Q9HUW6
UniRef50 UniRef50_Q9HUW6
UniRef90 UniRef90_Q9HUW6

Product

Feature Type CDS
Coding Frame 1
Product Name
CtpL
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -16.80
Kyte-Doolittle Hydrophobicity Value -0.204
Molecular Weight (kDa) 70.8
Isoelectric Point (pI) 4.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 397 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004474 (501 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4844
Search term: ctpL
Search term: CtpL

Human Homologs

References

Characterization of a Pseudomonas aeruginosa gene cluster involved in pilus biosynthesis and twitching motility: sequence similarity to the chemotaxis proteins of enterics and the gliding bacterium Myxococcus xanthus.
Darzins A
Mol Microbiol 1994 Jan;11(1):137-53
PubMed ID: 7908398
Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa.
Kuroda A, Kumano T, Taguchi K, Nikata T, Kato J, Ohtake H
J Bacteriol 1995 Dec;177(24):7019-25
PubMed ID: 8522505
Identification of CtpL as a chromosomally encoded chemoreceptor for 4-chloroaniline and catechol in Pseudomonas aeruginosa PAO1.
Vangnai AS, Takeuchi K, Oku S, Kataoka N, Nitisakulkan T, Tajima T, Kato J
Appl Environ Microbiol 2013 Dec;79(23):7241-8
PubMed ID: 24038698
Identification and characterization of two chemotactic transducers for inorganic phosphate in Pseudomonas aeruginosa.
Wu H, Kato J, Kuroda A, Ikeda T, Takiguchi N, Ohtake H
J Bacteriol 2000 Jun;182(12):3400-4
PubMed ID: 10852870