Pseudomonas aeruginosa PAO1, PA4872

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4872
Name
Replicon chromosome
Genomic location 5469115 - 5469978 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253559.1
GI 15600065
Affymetrix PA4872_at
Entrez 878100
GenBank AAG08257.1
INSDC AAG08257.1
NCBI Locus Tag PA4872
protein_id(GenBank) gb|AAG08257.1|AE004900_11|gnl|PseudoCAP|PA4872
TIGR NTL03PA04873
UniParc UPI00000C5E4E
UniProtKB Acc Q9HUU1
UniProtKB ID OADC_PSEAE
UniRef100 UniRef100_B7V1T5
UniRef50 UniRef50_A6VCY0
UniRef90 UniRef90_A6VCY0

Product

Feature Type CDS
Coding Frame 1
Product Name
oxaloacetate decarboxylase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.98
Kyte-Doolittle Hydrophobicity Value 0.121
Molecular Weight (kDa) 31.3
Isoelectric Point (pI) 5.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3B8I LYASE 11/01/07 Crystal Structure of Oxaloacetate Decarboxylase from Pseudomonas Aeruginosa (PA4872) in complex with oxalate and Mg2+. Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 265 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004500 (519 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4872

Human Homologs

References

Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
Narayanan BC, Niu W, Han Y, Zou J, Mariano PS, Dunaway-Mariano D, Herzberg O
Biochemistry 2008 Jan 8;47(1):167-82
PubMed ID: 18081320