Pseudomonas aeruginosa PAO1, PA4938 (purA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4938
Name
purA
Replicon chromosome
Genomic location 5542073 - 5543365 (- strand)

Cross-References

RefSeq NP_253625.1
GI 15600131
Affymetrix PA4938_purA_at
Entrez 877657
GenBank AAG08323.1
INSDC AAG08323.1
NCBI Locus Tag PA4938
protein_id(GenBank) gb|AAG08323.1|AE004907_1|gnl|PseudoCAP|PA4938
TIGR NTL03PA04939
UniParc UPI0000132B01
UniProtKB Acc Q9HUM6
UniProtKB ID PURA_PSEAE
UniRef100 UniRef100_B7V201
UniRef50 UniRef50_Q9KNX8
UniRef90 UniRef90_Q4KJ68

Product

Feature Type CDS
Coding Frame 1
Product Name
adenylosuccinate synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -7.25
Kyte-Doolittle Hydrophobicity Value -0.146
Molecular Weight (kDa) 46.8
Isoelectric Point (pI) 5.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004553 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4938
Search term: purA

Human Homologs

Ensembl 97, assembly GRCh38.p12
adenylosuccinate synthase like 1 [Source:HGNC Symbol;Acc:HGNC:20093]
E-value: 4.8e-92
Percent Identity: 43.9

References

Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+.
Poland BW, Fromm HJ, Honzatko RB
J. Mol. Biol. 1996 Dec;264(5):1013-27
PubMed ID: 9000627
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994