Pseudomonas aeruginosa PAO1, PA5173 (arcC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5173
Name
arcC
Replicon chromosome
Genomic location 5824787 - 5825719 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_253860.1
GI 15600366
Affymetrix PA5173_arcC_at
DNASU PaCD00008224
Entrez 881793
GenBank AAG08558.1
INSDC AAG08558.1
NCBI Locus Tag PA5173
protein_id(GenBank) gb|AAG08558.1|AE004930_4|gnl|PseudoCAP|PA5173
TIGR NTL03PA05174
UniParc UPI0000125DA7
UniProtKB Acc P13982
UniProtKB ID ARCC_PSEAE
UniRef100 UniRef100_P13982
UniRef50 UniRef50_P13982
UniRef90 UniRef90_P13982

Product

Feature Type CDS
Coding Frame 1
Product Name
carbamate kinase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.57
Kyte-Doolittle Hydrophobicity Value -0.062
Molecular Weight (kDa) 33.1
Isoelectric Point (pI) 4.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8CRV TRANSFERASE 05/11/22 Crystal Structure of the Carbamate Kinase from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 1.6 X-RAY DIFFRACTION 99.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004761 (489 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5173
Search term: arcC
Search term: carbamate kinase

Human Homologs

References

Sequence analysis and expression of the arginine-deiminase and carbamate-kinase genes of Pseudomonas aeruginosa.
Baur H, Luethi E, Stalon V, Mercenier A, Haas D
Eur J Biochem 1989 Jan 15;179(1):53-60
PubMed ID: 2537202
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994