Pseudomonas aeruginosa PAO1, PA5198

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5198
Name
Synonym: ldcA
Replicon chromosome
Genomic location 5850239 - 5851162 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253885.1
GI 15600391
Affymetrix PA5198_at
DNASU PaCD00008238
Entrez 880289
GenBank AAG08583.1
INSDC AAG08583.1
NCBI Locus Tag PA5198
protein_id(GenBank) gb|AAG08583.1|AE004932_10|gnl|PseudoCAP|PA5198
TIGR NTL03PA05199
UniParc UPI00000C5F4C
UniProtKB Acc Q9HTZ1
UniProtKB ID LDC_PSEAE
UniRef100 UniRef100_Q9HTZ1
UniRef50 UniRef50_Q9HTZ1
UniRef90 UniRef90_Q9HTZ1

Product

Feature Type CDS
Coding Frame 1
Product Name
LD-carboxypeptidase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.55
Kyte-Doolittle Hydrophobicity Value -0.059
Molecular Weight (kDa) 33.3
Isoelectric Point (pI) 6.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2AUM HYDROLASE 08/28/05 Active site Ser115Ala mutant of LD-carboxypeptidase PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 99.0
2AUN HYDROLASE 08/28/05 Active site His285Ala mutant of LD-carboxypeptidase PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 99.0
1ZRS HYDROLASE 05/21/05 wild-type LD-carboxypeptidase PSEUDOMONAS AERUGINOSA 1.5 X-RAY DIFFRACTION 99.3
1ZL0 STRUCTURAL GENOMICS, UNKNOWN FUNCTION 05/04/05 Structure of Protein of Unknown Function PA5198 from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 265 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004782 (380 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5198

Human Homologs

References

Pseudomonas aeruginosa LD-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow.
Korza HJ, Bochtler M
J Biol Chem 2005 Dec 9;280(49):40802-12
PubMed ID: 16162494
A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli.
Templin MF, Ursinus A, Höltje JV
EMBO J. 1999 Aug;18(15):4108-17
PubMed ID: 10428950