Pseudomonas aeruginosa PAO1, PA4350 (olsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4350
Name
olsB
Replicon chromosome
Genomic location 4878790 - 4879545 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253040.1
GI 15599546
Affymetrix PA4350_at
Entrez 881446
GenBank AAG07738.1
INSDC AAG07738.1
NCBI Locus Tag PA4350
protein_id(GenBank) gb|AAG07738.1|AE004851_6|gnl|PseudoCAP|PA4350
TIGR NTL03PA04351
UniParc UPI00000C5CD5
UniProtKB Acc Q9HW51
UniProtKB ID Q9HW51_PSEAE
UniRef100 UniRef100_Q9HW51
UniRef50 UniRef50_Q4ZP44
UniRef90 UniRef90_Q9HW51

Product

Feature Type CDS
Coding Frame 1
Product Name
OlsB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -2.77
Kyte-Doolittle Hydrophobicity Value -0.327
Molecular Weight (kDa) 28.2
Isoelectric Point (pI) 6.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 146 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003943 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4350
Search term: olsB
Search term: OlsB

Human Homologs

References

The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility.
Lewenza S, Falsafi R, Bains M, Rohs P, Stupak J, Sprott GD, Hancock RE
FEMS Microbiol Lett 2011 Jul;320(2):95-102
PubMed ID: 21535098
Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids.
Gao JL, Weissenmayer B, Taylor AM, Thomas-Oates J, López-Lara IM, Geiger O
Mol Microbiol 2004 Sep;53(6):1757-70
PubMed ID: 15341653