Pseudomonas aeruginosa PAO1, PA4704 (cbpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4704
Name
cbpA
Replicon chromosome
Genomic location 5283109 - 5283906 (+ strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253392.1
GI 15599898
Affymetrix PA4704_at
DNASU PaCD00008041
Entrez 881530
GenBank AAG08090.1
INSDC AAG08090.1
NCBI Locus Tag PA4704
protein_id(GenBank) gb|AAG08090.1|AE004884_8|gnl|PseudoCAP|PA4704
TIGR NTL03PA04705
UniParc UPI00000C5DD3
UniProtKB Acc Q9HV93
UniProtKB ID Q9HV93_PSEAE
UniRef100 UniRef100_W0YYF1
UniRef50 UniRef50_W0YYF1
UniRef90 UniRef90_W0YYF1

Product

Feature Type CDS
Coding Frame 1
Product Name
cAMP-binding protein A
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.64
Kyte-Doolittle Hydrophobicity Value -0.183
Molecular Weight (kDa) 29.7
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 168 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004353 (388 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4704
Search term: cbpA

Human Homologs

References

Cyclic-AMP-dependent activation of an inter-phylum hybrid histone-kinase complex reconstituted from sea urchin sperm-regulatory subunits and bovine heart catalytic subunits.
Hoshino K, Nomura K, Suzuki N
Eur J Biochem 1997 Feb 1;243(3):612-23
PubMed ID: 9057823
CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa.
Endoh T, Engel JN
J Bacteriol 2009 Dec;191(23):7193-205
PubMed ID: 19801409