Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5260
|
Name |
hemC
Synonym: popE |
Replicon | chromosome |
Genomic location | 5921494 - 5922435 (- strand) |
RefSeq | NP_253947.1 |
GI | 15600453 |
Affymetrix | PA5260_hemC_at |
DNASU | PaCD00008268 |
Entrez | 877673 |
GenBank | AAG08645.1 |
INSDC | AAG08645.1 |
NCBI Locus Tag | PA5260 |
protein_id(GenBank) | gb|AAG08645.1|AE004938_7|gnl|PseudoCAP|PA5260 |
TIGR | NTL03PA05261 |
UniParc | UPI000012C488 |
UniProtKB Acc | Q60169 |
UniProtKB ID | HEM3_PSEAE |
UniRef100 | UniRef100_B7V5F0 |
UniRef50 | UniRef50_Q4K3X3 |
UniRef90 | UniRef90_A6VE37 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
porphobilinogen deaminase
|
Synonyms |
hydroxymethylbilane synthase |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -6.67 |
Kyte-Doolittle Hydrophobicity Value | -0.085 |
Molecular Weight (kDa) | 33.6 |
Isoelectric Point (pI) | 5.26 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004841 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5260
Search term: hemC
Search term: porphobilinogen deaminase
|
Ensembl
110, assembly
GRCh38.p14
|
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value:
9.1e-60
Percent Identity:
41.9
|
Ensembl
110, assembly
GRCh38.p14
|
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value:
9.1e-60
Percent Identity:
41.9
|
Ensembl
110, assembly
GRCh38.p14
|
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value:
9.1e-60
Percent Identity:
41.9
|
Ensembl
110, assembly
GRCh38.p14
|
hydroxymethylbilane synthase [Source:HGNC Symbol;Acc:HGNC:4982]
E-value:
9.1e-60
Percent Identity:
41.9
|
Evidence for participation of aspartate-84 as a catalytic group at the active site of porphobilinogen deaminase obtained by site-directed mutagenesis of the hemC gene from Escherichia coli.
Woodcock SC, Jordan PM
Biochemistry 1994 Mar 8;33(9):2688-95
PubMed ID: 8117733
|
The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.
Mohr CD, Sonsteby SK, Deretic V
Mol Gen Genet 1994 Jan;242(2):177-84
PubMed ID: 8159168
|