Pseudomonas aeruginosa PAO1, PA2352

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2352
Name
Replicon	chromosome
Genomic location	2598700 - 2599827 (+ strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs
Comment	Structural similarity to 2OOG: glycerophosphoryl diester phosphodiesterase from Staphylococcus aureus (root-mean-square deviation: 1.5 angstroms)

Cross-References

RefSeq	NP_251042.1
GI	15597548
Affymetrix	PA2352_at
Entrez	881920
GenBank	AAG05740.1
INSDC	AAG05740.1
NCBI Locus Tag	PA2352
protein_id(GenBank)	gb|AAG05740.1|AE004661_7|gnl|PseudoCAP|PA2352
TIGR	NTL03PA02352
UniParc	UPI00000C5686
UniProtKB Acc	Q9I1C6
UniProtKB ID	Q9I1C6_PSEAE
UniRef100	UniRef100_Q9I1C6
UniRef50	UniRef50_D7I1J1
UniRef90	UniRef90_Q9I1C6

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative glycerophosphoryl diester phosphodiesterase Product Name Confidence: Class 3
Synonyms
Evidence for Translation	Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7)	-5.06
Kyte-Doolittle Hydrophobicity Value	-0.300
Molecular Weight (kDa)	41.1
Isoelectric Point (pI)	5.91

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543 Cytoplasmic Class 2 Periplasmic Class 1
Additional evidence for subcellular localization	Detetected in a periplasmic protein preparation by spheroplasting by lysozyme and MgCl2.(PMID:19333994)

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 382 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000339 (769 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2352 Search term: putative glycerophosphoryl diester phosphodiesterase

Human Homologs

References

Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen. Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM Proteomics 2009 Apr;9(7):1901-15 PubMed ID: 19333994

Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach. Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F J Biomol Struct Dyn 2020 Sep;38(15):4508-4520 PubMed ID: 31631799