Pseudomonas aeruginosa PAO1, PA5080

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5080
Name
Synonym: pip
Synonym: pap
Replicon chromosome
Genomic location 5719316 - 5720287 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253767.1
GI 15600273
Affymetrix PA5080_at
DNASU PaCD00008186
Entrez 880248
GenBank AAG08465.1
INSDC AAG08465.1
NCBI Locus Tag PA5080
protein_id(GenBank) gb|AAG08465.1|AE004921_2|gnl|PseudoCAP|PA5080
TIGR NTL03PA05081
UniParc UPI00000C5EEE
UniProtKB Acc Q9HUA3
UniProtKB ID Q9HUA3_PSEAE
UniRef100 UniRef100_Q9HUA3
UniRef50 UniRef50_Q87UX8
UniRef90 UniRef90_A6VDK3

Product

Feature Type CDS
Coding Frame 1
Product Name
prolyl aminopeptidase
Product Name Confidence: Class 2
Synonyms proline iminopeptidase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.27
Kyte-Doolittle Hydrophobicity Value -0.315
Molecular Weight (kDa) 36.5
Isoelectric Point (pI) 6.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 327 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004681 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5080

Human Homologs

References

Molecular cloning and characterization of a proline iminopeptidase gene from Neisseria gonorrhoeae.
Albertson NH, Koomey M
Mol Microbiol 1993 Sep;9(6):1203-11
PubMed ID: 7934933
Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri.
Sudo T, Shinohara K, Dohmae N, Takio K, Usami R, Horikoshi K, Osada H
Biochem J 1996 Oct 1;319 ( Pt 1)(Pt 1):99-102
PubMed ID: 8870654
Proline iminopeptidase gene from Xanthomonas campestris pv. citri.
Alonso J, García JL
Microbiology (Reading) 1996 Oct;142 ( Pt 10):2951-7
PubMed ID: 8885412