Pseudomonas aeruginosa PAO1, PA1523 (xdhB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1523
Name
xdhB
Replicon chromosome
Genomic location 1655346 - 1657745 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250214.1
GI 15596720
Affymetrix PA1523_xdhB_at
Entrez 879250
GenBank AAG04912.1
INSDC AAG04912.1
NCBI Locus Tag PA1523
protein_id(GenBank) gb|AAG04912.1|AE004580_12|gnl|PseudoCAP|PA1523
TIGR NTL03PA01524
UniParc UPI00000C53C1
UniProtKB Acc Q9I3J0
UniProtKB ID Q9I3J0_PSEAE
UniRef100 UniRef100_Q9I3J0
UniRef50 UniRef50_G8Q002
UniRef90 UniRef90_A6V7X9

Product

Feature Type CDS
Coding Frame 1
Product Name
xanthine dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -10.95
Kyte-Doolittle Hydrophobicity Value -0.233
Molecular Weight (kDa) 87.7
Isoelectric Point (pI) 6.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 322 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003834 (523 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1523
Search term: xdhB

Human Homologs

Ensembl 110, assembly GRCh38.p14
xanthine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12805]
E-value: 2.2e-174
Percent Identity: 44.8

References

Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes.
Leimkühler S, Kern M, Solomon PS, McEwan AG, Schwarz G, Mendel RR, Klipp W
Mol Microbiol 1998 Feb;27(4):853-69
PubMed ID: 9515710