Pseudomonas aeruginosa PAO1, PA1524 (xdhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1524
Name
xdhA
Replicon chromosome
Genomic location 1657738 - 1659192 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250215.1
GI 15596721
Affymetrix PA1524_xdhA_at
Entrez 879268
GenBank AAG04913.1
INSDC AAG04913.1
NCBI Locus Tag PA1524
protein_id(GenBank) gb|AAG04913.1|AE004580_13|gnl|PseudoCAP|PA1524
TIGR NTL03PA01525
UniParc UPI00000C53C2
UniProtKB Acc Q9I3I9
UniProtKB ID Q9I3I9_PSEAE
UniRef100 UniRef100_W0YRA1
UniRef50 UniRef50_A0A085JEM2
UniRef90 UniRef90_A6V7X8

Product

Feature Type CDS
Coding Frame 1
Product Name
xanthine dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.09
Kyte-Doolittle Hydrophobicity Value -0.110
Molecular Weight (kDa) 52.9
Isoelectric Point (pI) 6.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 355 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003833 (526 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1524
Search term: xdhA

Human Homologs

Ensembl 110, assembly GRCh38.p14
xanthine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12805]
E-value: 9.4e-56
Percent Identity: 32.9

References

Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes.
Leimkühler S, Kern M, Solomon PS, McEwan AG, Schwarz G, Mendel RR, Klipp W
Mol Microbiol 1998 Feb;27(4):853-69
PubMed ID: 9515710