Pseudomonas aeruginosa PAO1, PA1758 (pabB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1758
Name
pabB
Replicon chromosome
Genomic location 1897290 - 1898651 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250449.1
GI 15596955
Affymetrix PA1758_pabB_at
Entrez 879428
GenBank AAG05147.1
INSDC AAG05147.1
NCBI Locus Tag PA1758
protein_id(GenBank) gb|AAG05147.1|AE004601_12|gnl|PseudoCAP|PA1758
TIGR NTL03PA01759
UniParc UPI00000C5481
UniProtKB Acc Q9I2Y1
UniProtKB ID Q9I2Y1_PSEAE
UniRef100 UniRef100_Q9I2Y1
UniRef50 UniRef50_G8Q032
UniRef90 UniRef90_V6AGZ6

Product

Feature Type CDS
Coding Frame 1
Product Name
para-aminobenzoate synthase component I
Product Name Confidence: Class 2
Synonyms ADC-synthase
Evidence for Translation
Charge (pH 7) -4.82
Kyte-Doolittle Hydrophobicity Value -0.225
Molecular Weight (kDa) 49.6
Isoelectric Point (pI) 6.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 598 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003635 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1758
Search term: pabB

Human Homologs

References

Nucleotide sequence of Escherichia coli pabB indicates a common evolutionary origin of p-aminobenzoate synthetase and anthranilate synthetase.
Goncharoff P, Nichols BP
J Bacteriol 1984 Jul;159(1):57-62
PubMed ID: 6330050
Evolution of aminobenzoate synthases: nucleotide sequences of Salmonella typhimurium and Klebsiella aerogenes pabB.
Goncharoff P, Nichols BP
Mol Biol Evol 1988 Sep;5(5):531-48
PubMed ID: 3057324